Correlation between Leptin and Free Testosterone Levels in Transfusion-Dependent Thalassemia Male Patients

Background: Male hypogonadism is a clinical disorder of low testosterone and spermatozoa due to impaired production that can occur at one or more levels in the hypothalamic-pituitary-gonadal (HPG) axis. Apart from iron accumulation, also other mechanisms thalassemia patients, such as influence adipose tissue leptin. The study aimed assess relationship between leptin with free BMI transfusion-dependent thalassemia. Method: research design chosen was analytic cross-sectional. conducted adult polyclinic Cipto Mangunkusumo General Hospital Fatmawati Hospital, during period July - December 2022. samples used were male patients aged over 18 years who under control Thalassemia Polyclinic period. diagnosis had been previously established by high-performance liquid chromatography (HPLC) microcapillary examination. Result: Most major ß (87.8%), while HbE only 12.1%. Age distribution median 23 (minimum-maximum 18-42 years). symptoms erectile dysfunction decreased libido (12.1% 9%, respectively). From body mass index examination underweight (54,5%), normal weight 13 (39,5%), overweight 1 (3%), obese (3%). Of 33 95% did not reach puberty according their age (Tanner stage V). Conclusion: There an association significantly men.